Senior Payroll and Accounting Specialist

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🌍 Remote📍 US- Remote

About this role

Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.

Role Summary:

Spyre Therapeutics, Inc., is actively recruiting an experienced Senior Payroll and Accounting Specialist to join our accounting team. The Payroll and Accounting Specialist will be a key member of the accounting department, responsible for the integrity of the Company’s compensation cycles and equity administration. Responsibilities include full-cycle general ledger accounting, end-to-end payroll administration, equity platform management, and ensuring strict adherence to Sarbanes-Oxley (SOX) requirements. This position will support our increased operational needs as our company grows, playing a vital role in reconciling stock-based compensation, managing payroll tax compliance, and other accounting tasks as needed. Attention to detail and the ability to maintain precise account balances and general ledger accuracy are all essential skills for this position. The ideal candidate should be comfortable working collaboratively with cross-functional teams and independently and excel when faced with the unique challenges of a scaling organization.

Key Responsibilities:

  • Manage the full-cycle payroll process, including data entry, tax withholdings, and benefits deductions, etc.
  • Ensure all payroll activities align with federal, state, and local tax regulations, including the proper handling of withholdings and filings.
  • Perform regular audits of payroll data and reconcile payroll bank accounts to ensure accuracy and identify discrepancies.
  • Coordinate with HR to ensure accurate deductions for health insurance, retirement plans (401k), and other voluntary benefits.
  • Act as the primary point of contact for staff regarding pay-related inquiries, resolving issues related to paychecks or tax forms with high confidentiality.
  • Identify opportunities to streamline payroll workflows and improve the efficiency of the payroll software or HRIS.
  • Prepare and post monthly journal entries for payroll accruals, benefits, taxes, and other standard corporate expenses.
  • Maintain T&E system including syncing to the Company’s ERP and reviewing expense transactions for compliance with Company policies.
  • Assist in the preparation of monthly and quarterly financial statements by ensuring all payroll-related expenses are accurately categorized.
  • Maintain and document internal controls (such as SOX compliance procedures) to ensure the integrity of financial reporting and prevent fraud.
  • Facilitate the issuance of new equity awards (RSUs, Stock Options, or ESPP) by ensuring all grant agreements are properly executed and recorded in the equity platform.
  • Monitor vesting schedules and process stock option exercises, ensuring the accurate flow of data between the equity platform and payroll for tax withholding.
  • Other duties as assigned.

Ideal Candidate:

  • Bachelor’s degree in Accounting or related field
  • 5+ years of payroll and accounting experience
  • Experience managing payroll and tax withholdings across multiple states. Experience with international locations is a plus.
  • Proficiency in payroll/HRIS and equity management platforms (i.e. Rippling, Fidelity, E*TRADE)
  • Solid understanding of the lifecycle of various equity vehicles, including RSUs, NSOs, ISOs, and ESPPs.
  • A proven track record of handling highly sensitive executive compensation and employee financial data with total discretion.
  • Excellent organizational, analytical, prioritization and problem-solving skills in an environment of high volume of projects; detail-oriented
  • Possesses a professional demeanor, discretion and judgment
  • Ability to work effectively and establish and promote positive relationships
  • Self-starter who possesses initiative and ability to work alone while capable of driving business results without significant supervision
  • Must have schedule flexibility to meet the demands of monthly and quarterly close
  • Excellent verbal and written communication skills
  • Ability to work effectively with all employee levels and external contacts

What We Offer:

  • Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.
  • Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
  • Unlimited PTO
  • Two, one-week company-wide shutdowns each
  • Commitment to provide professional development opportunities.
  • Remote working environment with frequent in-person meetings to address complex problems and build relationships.

The expected salary range offer for this role is $110,000 to $130,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location. 

As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.

Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.

Please also be aware that all job postings will be listed on our website at spyre.com/careers/.

Frequently Asked Questions

Is the salary disclosed for the Senior Payroll and Accounting Specialist position at spyretherapeutics?
The salary for this Senior Payroll and Accounting Specialist role at spyretherapeutics is not publicly listed. Click "Apply Now" to learn more about the compensation package on their official careers page.
Is the Senior Payroll and Accounting Specialist job at spyretherapeutics remote?
Yes, this Senior Payroll and Accounting Specialist position at spyretherapeutics is remote, with team members based in US- Remote. You can work from home or anywhere in the supported regions.
Which team or department does the Senior Payroll and Accounting Specialist at spyretherapeutics belong to?
This Senior Payroll and Accounting Specialist position is part of the Finance department at spyretherapeutics. See the full job description for more information about the team structure and responsibilities.
How do I apply for the Senior Payroll and Accounting Specialist position at spyretherapeutics?
Click the "Apply Now" button on this page. You will be redirected to spyretherapeutics's official application portal hosted on greenhouse where you can submit your application directly.
When was the Senior Payroll and Accounting Specialist job at spyretherapeutics posted?
This Senior Payroll and Accounting Specialist position at spyretherapeutics was posted on May 29, 2026. Apply as soon as possible — early applications are often reviewed first.
Senior Payroll and Accounting Specialist
spyretherapeutics
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