Principal Engineer, Cloud Ops

JOB SUMMARY

We are seeking a talented and motivated Cloud Ops Engineer to join the tightly integrated technology and drug discovery operation at Iambic Therapeutics. You will work in the Software organization and work closely with the ML organization to help drive the Cloud Ops Roadmap, leading and supporting delivery of the roadmap goals for projects across the organization. You will work with teams developing and deploying Iambic’s drug discovery platform, Computational Science applications and Machine Learning models. You will also help deliver and support ISO 27001 compliant Cloud Ops processes.

This role is preferably Hybrid in Boston, then East Coast, San Diego, or Remote (with workspace support).

KEY RESPONSIBILITIES

• Support and contribute to the Cloud Ops roadmap, aligning infrastructure initiatives with business priorities.

• Provide technical leadership and drive architecture decisions across platform and infrastructure teams.

• Lead the design and evolution of scalable, highly available AWS cloud infrastructure.

• Build and operate production systems with a strong focus on reliability, performance, and cost efficiency.

• Design and manage cloud networking (VPN, VPC, routing, DNS, load balancing, secure connectivity).

• Implement Infrastructure as Code (Terraform) and automate provisioning and operations.

• Troubleshoot complex issues across distributed systems, including networking and performance bottlenecks.

• Apply security best practices and support the ISO 27001 compliance frameworks.

• Improve observability, CI/CD pipelines, and overall operational maturity.

• Mentor engineers in Cloud Services and influence Cloud Ops best practices across the org.

QUALIFICATIONS

• Minimum of 12 years of related experience with a bachelor’s degree; or 10 years and a master’s degree; or equivalent experience.

• Strong understanding of CI/CD pipelines.

• Strong Infrastructure as Code skills – for example in Docker, Packer/Ansible and Terraform/Terragrunt.

• Strong understanding of AWS services and underlying technologies such as AWS IAM service and managing Kubernetes as a service (AWS EKS) including managing zero-downtime upgrades and debugging issues with deployments, controllers, etc. Deployed in the cluster.

• Strong understanding of computer networks:

  • TCP/IP protocols.

  • IP block allocation across an organization.

  • Routing and VPN protocols.

  • AWS networking: VPCs, Transit Gateways, Customer Gateways, VPNs, flow logs, security groups, NACLs, etc.

  • Cloudflare networking experience.

• Understanding of issues facing ML deployments including model training and inference challenges.

• Ability to communicate with a variety of teams including IT, Computational Scientists, Software Developers, Cloud Ops and ML engineers

ABOUT IAMBIC THERAPEUTICS

Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.

MISSION & CORE VALUES

Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

PAY AND BENEFITS

We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.