Scientist II, ADC/AOC Conjugation

abbvie
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📍 MA📍 Worcester📍 Worcester, MA, United States📍 usFull time

About this role

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

Key Responsibilities:

  • Synthesis, purification, and characterization of antibody drug conjugates (ADCs) and antibody oligonucleotide conjugates (AOCs) on mg to gram scale under minimal supervision.
  • Development, optimization, and validation of conjugation protocols specifically for antibody oligonucleotide conjugates.
  • Optimization and validation of formulation buffers for bioconjugates.
  • Lead application and refinement of automated techniques for ADC/AOC synthesis and purification.
  • Collaboration with cross-functional teams to advance ADC/AOC discovery programs from conceptualization to early development.

Qualifications

Qualifications

  • B.S. degree with 7 years of experience or M.S. degree with 5 years’ experience in Biochemistry, Organic, Bioorganic or Analytical Chemistry, Molecular Biology, or related field.
  • Demonstrated hands-on expertise in laboratory-scale protein purification using Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), mixed-mode chromatography, and/or affinity chromatography. Experience with GE AKTA FPLC and Unicorn software is preferred.
  • Hands-on experience with relevant analytical techniques such as HIC-HPLC, SEC, IEX, RP-HPLC, LCMS and capillary electrophoresis techniques (e.g., CE-SDS, icIEF).
  • Strong experience in the discovery, design, synthesis, and purification of antibody drug conjugates (ADCs) and antibody oligonucleotide conjugates (AOC), including familiarity with associated chemistry and analytical methods.
  • Proven ability to independently design experiments, troubleshoot technical issues, and deliver high-quality scientific output with attention to detail, and the ability to thrive in a fast-paced, cross-disciplinary team environment.
  • Excellent written and oral communication skills, with a strong record of collaboration and innovation.

Preferred:

  • Previous experience with linker chemistry and payload conjugation strategies specific to oligonucleotide therapeutics.
  • Experience troubleshooting or optimizing the stability and delivery of antibody-oligonucleotide conjugates.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

  • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role atthe time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors includinggeographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​

  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

  • This job is eligible to participate in our short-term incentive programs. ​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested,and determinable. The amount and availability of  any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to aparticular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion,consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html

Frequently Asked Questions

Is the salary disclosed for the Scientist II, ADC/AOC Conjugation position at abbvie?
The salary for this Scientist II, ADC/AOC Conjugation role at abbvie is not publicly listed. Click "Apply Now" to learn more about the compensation package on their official careers page.
Where is the Scientist II, ADC/AOC Conjugation position at abbvie located?
This Scientist II, ADC/AOC Conjugation role at abbvie is based in MA, Worcester, Worcester, MA, United States, us. The position is listed as on-site or hybrid. Check the full job description or apply directly to confirm the work arrangement.
Is the Scientist II, ADC/AOC Conjugation role at abbvie full-time or part-time?
This is listed as a Full time position. It is posted as a Scientist II, ADC/AOC Conjugation role at abbvie.
How do I apply for the Scientist II, ADC/AOC Conjugation position at abbvie?
Click the "Apply Now" button on this page. You will be redirected to abbvie's official application portal hosted on smartrecruiters where you can submit your application directly.
When was the Scientist II, ADC/AOC Conjugation job at abbvie posted?
This Scientist II, ADC/AOC Conjugation position at abbvie was posted on Jun 5, 2026. Apply as soon as possible — early applications are often reviewed first.
Scientist II, ADC/AOC Conjugation
abbvie
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