Senior Scientist II, Brain Transport Biology

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

At AbbVie, we are dedicated to solving some of the world’s most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. The Discovery Neuroscience In Vivo Pharmacology group in Cambridge, Massachusetts, is seeking a highly skilled and self-motivated Senior Scientist to join a dynamic team supporting target identification, validation, and drug transport facilitation over brain barriers. The successful candidate will drive scientific innovation, has experience making tangible contributions to the discovery pipeline, and has people and project management experience.

Responsibilities:

• Responsible for design and implementation of in vivo testing of multispecific biologics, small molecules, and siRNAs to support projects in the areas of Alzheimer’s and Parkinson’s disease
• Serve as an in vivo representative in cross-functional teams with Discovery Biotherapeutics, DMPK, and Development Sciences colleagues, providing project updates, analysis, and strategic advice
• Proactively translate department/project team scientific questions into well-designed experiments, utilizing internal and external resources 
• Identify and solve technical problems independently, implement new assays and workflows, conceive and implement innovative research ideas
• Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions
• Collaborate with cross-functional partners at various AbbVie sites to advance candidates through discovery milestones
• Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor
• Mentor / matrix manage junior scientists, and be accountable for the effective performance of the team
• Ensure consistency and quality of technical reports
• Uphold impeccable research-related & corporate compliance standards 
• May author or co-author peer-reviewed scientific papers or patents

Qualifications

Minimum Qualifications:

• Bachelor’s Degree and typically, 12 years of experience, Master’s Degree and typically 10 years of experience, PhD and typically 4 years of experience.
• Background in receptor and / or transporter biology and targeted delivery
• Background in brain barriers biology
• Experience with in vivo models of neurodegeneration, particularly with models of Alzheimer’s and Parkinson’s Disease
• Experience in assay development for target identification and validation, mechanism of action studies, biodistribution and biomarker analysis. Proven ability to troubleshoot and refine assays and workflows
• Proven track record in characterizing complex biotherapeutics in vivo (biologics, small molecules, siRNA)
• Proven track record of working in multidisciplinary in vivo pharmacology teams, demonstrated ability to collaborate effectively in a dynamic, cross-functional matrix environment
• Experience managing direct reports, including providing performance evaluations and development opportunities
• Excellent organizational skills, strong data analysis and critical thinking skills, and the ability to manage multiple projects simultaneously
• Goal-oriented and highly self-motivated team player with excellent verbal and written communication skills with experience contributing to technical reports and publications

Desired Qualifications:

• Experience operating effectively in a matrixed, fast-paced discovery organization
• Experience in managing external collaborations
• Experience with ex vivo readouts including immunohistochemistry and biochemistry (e.g., ELISA, WB, qPCR, ddPCR). Experience with image analysis
• Familiarity with CNS-relevant biology and genetic medicine applications

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our long-term incentive programs. ​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html