Software Engineer, Infrastructure

chaidiscovery· Engineering
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📍 San Francisco officeFullTime

About this role

About Chai Discovery

Chai is a research lab working on AI to unlock biology. Our models design new molecules for new medicines. We are changing how biologists develop drugs, just as language models are changing how engineers write code. Our vision is a design suite for molecules, with applications across life sciences, agriculture, materials and beyond.

Our founders have been at the forefront of this field from the beginning. We are backed by Thrive, General Catalyst, OpenAI, Dimension and other tier-one investors. We partner with global life sciences companies like Eli Lilly on deals that are transforming industry.

We are known for talent density, rigorous research and pace of execution.

About the role

We are hiring an engineer obsessed with building systems and infrastructure that are as simple as possible while being flexible and resilient. You will build the compute and infrastructure systems underpin our product surface, model inference, and evaluation suite. You’ll work closely with product engineers, researchers, and our commercial team.

You have built services that developers love, moved and scaled AI/ML systems into production, and can help us predict and preempt objections that might prevent leading biopharma organizations from adopting our platform.

After years of foundational R&D, Chai's models are moving beyond protein structure prediction into real-world therapeutic engineering. This is a chance to bring the most advanced AI drug design models to market, working alongside a craft-obsessed team of micro pessimists and macro-optimists.

About you

You are mission-driven and want to define the gold standard for purposeful AI technology. You should have:

Software experience:

  • Bachelor’s degree or equivalent experience in Computer Science or related field.

  • 5+ years experience building production systems with proven + modern tooling, working with platform, security, and product teams.

  • You can see around infrastructure corners.

  • Have had end-to-end ownership of 24x7 infrastructure observability, alerting and incident response.

  • Have been part of 0-to-1 buildouts as well as 1-to-n scale-ups, have the scars to prove it, and bring an always-evolving playbook of best practices and philosophies with you wherever you go.

Communication & collaboration

  • Enjoy pair-reviewing code, writing docs, and sharing knowledge with teammates.

  • Able to explain technical trade-offs to non-engineers and to translate scientific requirements into engineering tasks.

Mindset:

  • Take ownership of what you build... you are "on call" by default.

  • Mission- and purpose-driven; you like the idea of your life's work going to create better cures

  • Driven to iterate fast with a bias for shipping—without breaking things

  • Question assumptions, with diplomacy.

  • Clear communicator and respectful colleague.

  • Operate well under pressure and thrive in fast-moving environments.

We offer

The opportunity to work at the frontier of AI, with world-class people, on a mission that matters. We protect & promote a culture of high velocity and ownership. We offer highly competitive compensation.

Frequently Asked Questions

Is the salary disclosed for the Software Engineer, Infrastructure position at chaidiscovery?
The salary for this Software Engineer, Infrastructure role at chaidiscovery is not publicly listed. Click "Apply Now" to learn more about the compensation package on their official careers page.
Where is the Software Engineer, Infrastructure position at chaidiscovery located?
This Software Engineer, Infrastructure role at chaidiscovery is based in San Francisco office. The position is listed as on-site or hybrid. Check the full job description or apply directly to confirm the work arrangement.
Is the Software Engineer, Infrastructure role at chaidiscovery full-time or part-time?
This is listed as a FullTime position. It is posted as a Software Engineer, Infrastructure role in the Engineering department at chaidiscovery.
Which team or department does the Software Engineer, Infrastructure at chaidiscovery belong to?
This Software Engineer, Infrastructure position is part of the Engineering department at chaidiscovery. See the full job description for more information about the team structure and responsibilities.
How do I apply for the Software Engineer, Infrastructure position at chaidiscovery?
Click the "Apply Now" button on this page. You will be redirected to chaidiscovery's official application portal hosted on ashby where you can submit your application directly.
When was the Software Engineer, Infrastructure job at chaidiscovery posted?
This Software Engineer, Infrastructure position at chaidiscovery was posted on Nov 25, 2025. Apply as soon as possible — early applications are often reviewed first.
Software Engineer, Infrastructure
chaidiscovery
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